Sarah Randolph Talcott was born in South Carolina in 1891 to George Russell Talcott and Frances Mason Berry. She attended The Virginia Hospital Training School for Nursing and was part of the last class to graduate from the program. The school originally began under the University College of Medicine which merged with the Medical College of Virginia in 1913. Talcott later worked as a nurse in Alexandria Hospital. She married Marion Nimmo Fisher in 1917 and they had three children. Talcott died in 1966.