The George Mason University Office of the President records contains a broad spectrum of materials originating within, received, or accessed by the George Mason University (GMU) Office of the President. These materials include, but are not limited to, correspondence, studies, reports, speeches, meetings minutes, scrapbooks, audio-visual media and photographs.

The collection contains materials from the institution's beginning in 1949 as a subsidiary of the University of Virginia through the early 2010s. These materials chart the development, both culturally and physically, of the institution through the lens of its directors', chancellor's and presidents' correspondence, reports, and other administrative documents.

In addition to providing information about GMU's academic and physical development, the collection provides a view of the sociocultural development of Northern Virginia and, by extension, the United States. Notable moments and cultural shifts in American history, such as the Civil Rights movement, the Vietnam War, diversity awareness, and the September 11 attacks are referenced within collection materials.

Series 1: Annual Reports contains the George Mason annual reports, compiled by the sitting college director or, later, university president. These reports documented the rate of change during George Mason's first twenty years.

Series 2: Early History contains correspondence, reports, campus development plans, and other documentation produced during George Mason's early years under directors John Norville Gibson Finley and Robert Reid.

Series 3: Lorin A. Thompson contains materials such as correspondence, administrative meetings minutes, Civil Rights Act compliance documents, land acquisition and building plans, memoranda, photographs, scrapbooks, and reports dating from the tenure of Lorin A. Thompson.

Series 4: Vergil H. Dykstra contains materials such as budget reports, administrative meetings minutes, and enrollment statistics from the tenure of Vergil H. Dykstra.

Series 5: Robert C. Krug primarily contains correspondence from the tenure of Robert C. Krug.

Series 6: George W. Johnson contains a wide variety of materials including correspondence, speeches, and reports from the tenure of George W. Johnson.

Series 7: Alan G. Merten contains a wide variety of materials including correspondence, speeches, and reports from the tenure of Alan G. Merten.

Series 8: Ángel Cabrera contains 2013 Spring and Winter Commencements planning documents, Colonial Athletic Association meetings minutes and correspondence, and holiday greetings and event invitation cards from the tenure of Ángel Cabrera.