Prince Edward County was named in honor of Edward Augustus, a son of Prince Frederick Louis, a grandson of George II, and a younger brother of George III. The county was formed from Amelia County in 1753.

In seventeenth- and eighteenth-century Virginia, the term "tithable" referred to a person who paid (or for whom someone else paid) one of the taxes imposed by the General Assembly for the support of civil government in the colony. In colonial Virginia, a poll tax or capitation tax was assessed on free white males, African American slaves, and Native American servants (both male and female), all age sixteen or older. Owners and masters paid the taxes levied on their slaves and servants. For a more detailed history of tithables, consult the Library of Virginia's website for Colonial Tithables