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The correspondence of Clark family members, mainly that of Frank Wells Clark and Friend E. Clark. Frank Wells Clark was a student at West Virginia University and Harvard Law School and later established a law practice at New Martinsville. Friend E. Clark was a student at West Virginia University and Johns Hopkins University and later taught chemistry at State College, Pennsylvania, and West Virginia University. Included are the letters of Friend Clark when he traveled to Europe where in 1908 he was visiting professor at the University of Berlin. Cities and places he visited were Berlin, Florence, Gibraltar, Gottingen, Munich, Naples, Rome, Venice and Vienna. There is his professional correspondence as a West Virginia University chemistry professor which covers his recommendations to colleagues, businesses, and stockholders about technical matters. Also there are presentations on New Martinsville, Kanawha Valley, West Virginia and chemistry. Included is the correspondence of Mrs. Friend E. Clark in her capacity as an officer and member of the Crippled Children's Society containing fundraising letters, statistics, organizational bylaws, and constitutions. Correspondents include Franklin D. Roosevelt, John W. Davis, William G. Conley, and H. Guy Kump.

Pamphlets include Henry Ruffner's antislavery pamphlet, 1847, and his Union speech, 1856. Subjects of the manuscripts and correspondence include family history; travel; Kanawha Salt Works; schools in Virginia and Kanawha County; Lane Seminary Library; Presbyterian Church; slavery, coal, gas, iron, and timber; Johns Hopkins, Washington and Lee, Harvard, Hobart, Cornell, and Hampden-Sydney colleges; Greenbrier County; Alabama; election of 1904; University of Virginia; Kanawha Valley floods; Venezuela; American Colonization Society; and the Philippine Islands. Persons mentioned or commented on include Philip Doddridge, John Letcher, Hugh Mercer, and Nelson A. Miles. Correspondents include Charles H. Ambler, John Eaton, John P. Hale, H.R. Helper, W.S. Laidley, David L. Ruffner, John W. Wayland, and William L. Wilson.