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Collection of records from the Planning, Marketing, and Communications department of the Health Sciences Center mostly related to the dedication of the Robert C. Byrd Health Sciences Center in June 1993 with Senator Byrd in attendance. It includes photographs, planning papers, pamphlets, and motion picture material. Most of the audio-visual material documents Byrd's participation in the event. There are also a few photos of Byrd earlier in his life, and a folder on cancer awareness and the Cancer Center. There is a compact disc and VHS tape of a motion picture documentary on Senator Byrd entitled "The Soul of the Senate" (2005), and six additional VHS tapes of footage, including four of the Health Sciences Center dedication (one featuring President Bill Clinton), an interview with Byrd (undated), and a tape of West Virginia Governor Caperton discussing Senator Byrd (undated).

Correspondence and miscellaneous papers of: a Monroe County, West Virginia, farmer and politician; his wife, Harriette Boswell Alexander; their daughters, Isabel and Alice Beulah; Alice's husband, Frank Hereford, U.S. senator from West Virginia; and his daughter, Katherine Hereford Stoddard. There is one folder of business papers, 1820-1841, of Thomas Edgar; a few letters from Caperton's son, John, while a cadet at the Camp of Instruction, Richmond, 1861; a folder of letters concerning Isabel's trips through the American West, the British Isles, and Europe; and a folder on family genealogy. Subjects include mid-nineteenth century life in Union, Monroe County; the excitement in Virginia following John Brown's raid; Washington, D.C., and the slavery controversy, 1860; the secession crisis in Virginia; impressment of material in Monroe County by Union troops; the effect of the war on the social and economic life of Richmond; work of the Ladies Relief Hospital in Lynchburg; and the aftermath of war in Virginia.