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This is a collection of letters and documents tracing the personal and business life of an eastern panhandle West Virginia family. The papers concern a broad range of political, social, financial, and legal topics, particularly focusing on J. Hammond Siler, Jr., his parents, J. Hammond Siler, Sr. and Jessie Castleman Siler (residents of the Town of Bath better known as Berkeley Springs). Also includes correspondence and other papers from related families. Subjects include banking, the Civil War, the Episcopal church, secession of Virginia, Virginia Loyalty Oath, women's diaries, and women's letters and papers. A notable item in the collection is the diary of Anne Doyne Wolff Strother, wife of artist and writer David Hunter Strother, documenting a trip with husband and daughter Emily to New Orleans in 1857 (S2/Box 67, folder 1a).

The Historical Photograph Collection is largely comprised of materials created by or for the Mount Vernon Ladies' Association. Some of the earliest photographs of the estate were created and sold to visitors by the Association as a means of income. Those efforts helped to establish an important collection of 19th century views. The collection spans the 1850s to 2000s and includes over 140 linear feet of analog material providing a visual history of the Mansion, outbuildings, tombs, grounds, events, visitors, collection objects, personnel, and changes throughout the estate.

Series 1: Group A, Acc. 78 T97 and 1992.63: Papers, 1856-1895, of John Tyler, Jr., post Civil War Republican Party activist. Subjects covered by the collection include alcoholism, Republican Party politics, Presidential elections, political patronage, Reconstruction, Methodist Episcopal Church, Florida, Braxton Bragg, and the Fenian Brotherhood. Prominent correspondents include Charles Francis Adams, Chester Alan Arthur, Pierre G. T. Beauregard, James Gillespie Blaine, James Buchanan, Jefferson Davis, Benjamin Stoddert Ewell, Henry Stuart Foote, Nathan Bedford Forrest, James A. Garfield, John Brown Gordon, Horace Greeley, Wade Hampton, Rutherford B. Hayes, Andrew Johnson, Joseph Eggleston Johnston, L. Q. C. Lamar, William Mahone, Raphael Semmes, William Henry Seward, John Sherman, Leroy Pope Walker, and William Lowndes Young. Acc. 1992.63 consists of letters of John Tyler, Jr., son of the President, to Mrs. Laura Holloway, author of a book on the ladies of the White House. Letters written from Washington, D.C.

Correspondence, miscellaneous family papers, nineteenth century school records, ledgers, bank books, and memorabilia of Hugh F. Sayre and family of Parkersburg, Reedy, St. Marys and West Creek, West Virginia. Some material relates to oil and gas leases on the Sayre family farm and Sayre's invention of a scientific alphabet called EBDECORD.