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Letters, chiefly 1765-1817, of the Blair, Banister, Braxton, Horner, and Whiting families. Correspondents include John Blair (1732-1800), Anne (Blair) Banister and Mary (Blair) Braxton Burwell Prescott. Many of the letters are written by women.

Professional and personal papers, 1745-1892, of the Galt family of Williamsburg, Virginia. Papers primarily concern the Galt family's work at the Eastern State Hospital, including apothecary shop daybooks, account books, medical daybooks, clinical notebooks, weather diaries, commonplace books, reports, medical notes, lecture notes, correspondence, and other. The personal papers consist of diaries, letters, scrapbooks, school notes, financial papers, memoirs, and other material.

The collection covers the dates 1750-1982 and consists chiefly of the personal and business correspondence, financial and legal documents, literary documents, and family history and genealogy notes of the Galt family. The collection also contains clippings, photographs, and personal mementos such as artifacts.

Copies of letters, 1781-1783, from George Wythe, Williamsburg, Va. , one to John Adams and another to Thomas Jefferson concerning the use of the College of William and Mary as a hospital. Also includes a magazine article about Wythe; newspaper copy of William Munford's oration at Wythe's funeral; correspondence, 1921, of Robert M. Hughes concerning a monument for Wythe's grave; a form book of Peter Tinsley, clerk of the High Court of Chancery which gives "Forms of Injunctions," Forms of Orders," "Certificates,"Processes,"Executions," "Rules of Court," "Bonds," and "Appeal," of chancery cases from the Richmond High Court (1779-1802); several engravings of Wythe and bills of complaints in lawsuits.

Papers, primarily 1770-1907, of the Tucker and Coleman families of Williamsburg, Winchester, Lexington, Staunton and Richmond, including papers of: St. George Tucker (1752-1827), Nathaniel Beverley Tucker (1784-1851), Henry St. George Tucker (1780-1848), Ann Frances Bland (Tucker) Coalter (1779-1813), John Coalter (1769-1838), and John Randolph of Roanoke (commonplace book is in box 64B), as well as other family members.