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The University Archives Artifact Collection is an artificial collection of artifacts and memorabilia documenting and related to the College of William and Mary. Artifacts received by the University Archives that are not part of the records of an individual university department or personal papers are made a part of the University Archives Artifact Collection.

The collection comprises mostly of anatomical illustrations of humans and animals by professional medical illustrators and medical practioners, but there is a good number of caricatures. Many of the images depict 20th century surgical prodedures; there are also physiological illustrations included in the collection. Most items are drawn in pencil on illustration paper with cardboard backing. In addition, there are some drawings in notepads and on tracing paper.

Colored etching by G[eorge] Cruikshank: Source of the Southwark Water Works, or [headed] Salus Populi Suprema Lex. Published by S. Knight, [1832]. 51x32.5cm. Printed on broadsheet with text poem beneath: Royal Address of Cadwallader... water-king of Southwark [John Edwards]. Concern at pollution and threat to public health.

The collection also contains miscellaneous manuscripts and account books. Included in this material are: land grants, 1761 and 1766, for land in Fairfax and Frederick counties, Va.; eighty-five survey maps of Frederick, Fauquier, and Loudoun counties, Va. and Berkeley and Hampshire counties, W. Va.; road petitions, 1743-1828, for Frederick County; affidavits for Revolutionary War service; correspondence, 1923-1930, of the Improved Order of Redmen, Great Council of Virginia; letters written to W. H. H. Flick; account books of merchants in Frederick County, , Lexington, Va. and Harrisonburg, Va.; and account books of the Richmond Whig (1837), the Lexington Gazette; and the Southern Collegian (student newspaper at Washington and Lee College). There is also a daybook which contains copies of letters, notes and bonds written by Philip Nelson to Powhatan R. Page; notes on the Washington and Custis families and the building of "Arlington"; and notes concerning John Randolph of Roanoke and the Underwood Constitutional Convention in Richmond.

Microfilm include State Land Office Records; S. Bassett French, Biographical Sketches; Mott-Alston Collection of Colonial Families; Confederate Service Records of Virginia Soldiers; Revolutionary War, Public Service Claims; Revolutionary War, Public Service Claims; Revolutionary War, Bounty Warrants; Revolutionary Pensions; Revolutionary War, Rejected Claims; Family Genealogical Notes; and List of Baptist records at the University of Richmond.

Deeds, wills, court orders, marriage and other records for Accomack County; Alexandria City; and parish registers, vestry books, marriage bonds, etc. for Albemarle County, Alexandria City, Abingdon, Atrim and Augusta parishes.

This collection consists of 17 folders. In addition to the untitled book, designated the "Von Frieling Sammelband," the collection contains photocopies of the book and materials related to the 20th century version of Von Frieling's green butter salve, also called Von Frieling's plaster salve. These materials include documentation and packaging for the salve, patent paperwork, correspondence, and various items related to herbal medicine and early German printing, as well as two samples of the salve itself.

The Waller family papers contains original documents including correspondence, deeds, land indentures, receipts, photographs and other papers related to the genealogical research of the Waller family by Anne Waller Reddy (1890-1971). Materials contain those belonging to or documenting Governor Littleton John Waller Tazewell as well as Benjamin and John Waller.

Negative photostats of items from the correspondence of the Rev. William Dawson and the Rev. Thomas Dawson, both of whom were commissaries of the Church of England in Virginia and presidents of the College of William and Mary. Prominent correspondents include Patrick Henry, Samuel Davies, John Blair and Robert Dinwiddie.