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The Carter Papers include correspondence relating to Carter's work on yellow fever and malaria as a surgeon in the Marine Health Service (later United States Public Health Service) and notes for drafts of his Yellow Fever: An Epidemiological and Historical Study of its Place of Origin. (Baltimore: The Williams and Wilkins Company, 1931). Included are photographs of and newspaper clippings about Carter, in addition to a small collection of reprints and publications by Carter and others. Also included is the correspondence of his daughter, Laura Armistead Carter with Frederick F. Russell and other members of the Rockefeller Foundation International Health Board, Wade Hampton Frost, of Johns Hopkins University, and others concerning her collaboration with Frost in the editing and publication of Carter's book. Also included are a series of eighteenth-century to mid-nineteenth-century documents principally belonging to Carter's great-grandfather, George Mason, of Spotsylvania and Caroline Counties, Virginia and to Mary Ann Brown, sister of Carter's mother.

This collection of historic manuscripts dates from 1607-1933, with the bulk of materials dating from 1738-1868. The correspondence, journals and diaries, legal and financial records, estate documents, and printed ephemera in the collection primarily relate to the Washington and Custis families, the Revolutionary War, and society life in antebellum Washington D.C. and Virginia.

This collection consists of four handwritten seventeenth-century Italian wills.

This collection primarily includes personal correspondence and legal and business papers of the Berkeley Family . Interfiled with these papers are extensive papers of the closely-related Noland family . The joined collection comprises about 20,000 items (ca. 85 Hollinger documents boxes on about 38 feet of shelving) dating between 1653 and 1930, with the heaviest concentration in the nineteenth century.

Album amicorums were an early friendship and autograph book. This volume is bound in contemporary calf skin with a gilt embossed plate on both covers and the bookbinder's mark WL; all edges are gilt. It is in a modern slipcase. The manuscript is ink on paper comprised of 173 leaves with twenty-eight miniatures in gouache including one full-page allegorical depiction on the verso of the first leaf, twenty-four coats of arms (two mounted) mostly with motto and entry, two full-page depictions of women's costumes (one with coat of arms), and one depiction of a flag-waving lansquenet, a German mercenary foot soldiers, as well as nine text entries without pictorial contribution. Most of the entries date 1605-1609, all written in Latin, mainly by students or scholars from the University of Freiburg im Breisgau belonging to notable families of Southwest Germany and Alsace.

The Manuscripts Artifact Collection includes artifacts from a variety of personal papers and organizational records collections, as well as items acquired individually.