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This collection consists of a physician's daybook kept by Dr. George Williamson of New Market, Virginia, whose practice extended throughout the Shenandoah Valley. Spanning 1807-1819, the daybook records names of patients, treatments, and payments (for both Caucasians and African Americans). Treatments range from inoculations and venereal disease to all night vigils.

Journal, 1794-1840, of Henry Bedinger, merchant of Mecklenburgh, Shepherdstown, Martinsburg, and Berkeley County, West Virginia.

Journal, 1801-1810, of James Bailey, leather goods dealer, Lexington, Virginia.

Journal, 1820-1858, of Matthew Thomson, Sheriff and Justice of the Peace of Clark County, Ky. and his son Sanford Thomson. Entries concern the records of sheriff and justice of the peace; genealogical information concerning the Thomson, Whaley, Bigger, Haynie, Wilkerson, Daniel and Hay families; weather reports and record that an earthquake occurred 15 July 1824; land surveys; remedies for cancer, dropsy and scurvy; lists of slaves and their children with birth dates; marriage, birth and death dates of various residents of Clark County; and lists of Tory officers and information on regulators. 168 p. : bound volume ; 37 cm.

Collection contains account journals, some papers and other items of James M. Nicolson, a general merchant in Gloucester County, Virginia (1802-1869), an account book kept by Nicolson and Capt. John L. Hibble as Assistant Quarter Masters of the 26th Virginia Regiment, 1861-1864 (discusses slaves labors); a letter book of H. Yeatman & Co., merchants of Gloucester Court House, 1869-1870, which also contains some of Nicolson's correspondence; and ledger accounts, 1892-1899, for farming at 'Severn Hall', Gloucester County, Va. Includes a list of slaves hired out on 23 Dec. 1802.

Journals, 1804-1806, and 1817, of Robert Swan and Daniel C. Brent, Richland Mill, [Stafford County, Va.] which contains grist mill and general store accounts.

Two ledgers, two journals and a daybook, 1802-1859, of Samuel B. Finley, merchant, of Lexington, Va. Ledger "B" (MsV Ame29) contains accounts concerning the estate of John Tate (Samuel Finley, executor); daybook (MsV Ame 31) contains an inventory , 1813, of goods put into partnership with William Shields and A. Shields and a manuscript arithmetic copybook, 1832; and ledger, 1842-1842 (MsV Ame33) contains notes, 1851-1867, concerning a fruit orchard.