- Captain Rufus D. Pettit Papers (MS093), 1863/186518
- Cazenove Family Papers (MS212), 1786/1970250
- Cazenove and Co. Ledger (MS293), 1857/18615
- Chapman Family Collection (MS274), 1828/196311
- Chapman-Southerland Collection (MS409), 1878/19136
- Charles L. Sampson Collection (MS126), 1841/198678
- Christ Church Records (MS306), 1873/19451
- Civitan and Civinette Clubs of Alexandria Collection (MS038), 1942/197813
- Curtin Family Papers (MS101), 1885/200018
- Daniel O'Sullivan Collection (MS141), 1850/191216
- Delos H. Smith Collection (MS307), 1900/195013
- Dickman Collection (MS069), 1968/198510
- Early Building and Repair Permits (MS040), 1890/194982
- Edith Moore Sprouse Papers (MS313), 1960/2003106
- Edward L. Daingerfield Collection (MS121), 1886/19254