- Anonymous Scrapbook, 1885/18901
- Archibald McClean Letter to Charles S. Morgan, 18291
- Ayres Papers, 1833/18551
- Brown, Coalter, Tucker Papers (I), 1790/19291
- C. W. Murdaugh Papers, 1853/18781
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Charles Triplett O'Ferrall Papers, 1856/1904, bulk 1867/18931
- Daniel Webster Letter to Norton Quincy Tirrelll, 18411
- George G. York Letter, 18981
- Henry Ward Beecher Manuscript, 18641
- James Madison, Sr. Papers, 1792/19311
- John Buchanan Floyd Papers, 1831/18621
- John Minor Botts Letter to Charles Lanman, 18581
- John Thomas Harris Autobiographical Letter to Charles Lanham, 18591
- John W. Wise Letter to John E. Roller, 18841