- "Home School for Young Boys" Broadside, 18701
- Academic Departments - Record Group 94
- Adair-Hutton Department Store Fire Photograph, 19491
- African-American Heritage Exhibit materials, 1992/20011
- Alexander Lockhart Nelson papers, 1848/19021
- Anderson Family papers, 1755/19581
- Anne Carter Lee Records, 1993/19941
- Cabinet Photograph of Lexington, Virginia, 1880/18951
- Campbell Family Papers, 1843/19501
- Charles Manson Crutchfield Collection of Memorabilia, 1882/1914, bulk 1880/18897
- Christian Social Services Report, Lexington, Virginia, 19301
- City Manger's Report on Lexington, Virginia Downtown Restoration Project, 19781
- Collection of Photographs of Lexington, Va., 1857/19691
- Collection of research materials about William R. Clark, 1950/20081
- Conrad M. Speece letter, 17911