- Audrey Emmons Architectural Collection, 1974/19975
- Bailey-Law Collection, 1825/19714
- Baldwin Family Letters, 1861/18971
- Black Women at Virginia Tech Oral History Project Records, 1967/2000, bulk 1994/200015
- Blake W. Corson, Jr., Papers, 1861/1984, bulk 1934/197936
- Charles Goodsell Collection, 1982/200157
- Charles Willis Cassell Family Papers, 1883/19508
- Dorothy Alexander Architectural Collection, 1939/19942
- Eleanore Pettersen Architectural Collection, 1915/2003, bulk 1950/200061
- Episcopal Diocese of Southwestern Virginia Records, 1866/2004, bulk 1919/1969207
- Geraldine Pontius Architectural Collection, 1966/19902
- Leonard J. Currie Papers, 1920/200147
- Mary Brown Channel Architectural Collection, 1936/2002, bulk 1936/19501
- Norfolk & Western Railroad and Railway Company Records, 1876/19351
- Records of the Office of Faculty Affairs, 1995/20161