- Sally H. Thomas papers, 1968/201077
- Samuel Price, Lawyer and Politician, Papers, 1788/18886
- Samuel Vaughan Wilson Papers, 1945/2017219
- Samy Elias, Engineering Professor, Personal Rapid Transit Records, 1967/198024
- Sheet Music Collection, 1823/19568
- Siler Family Papers, 1848/196856
- Smithey & Boynton, Architects & Engineers Records, 1922/19851
- Smithfield Plantation House Architectural Drawings2
- Soil Conservation Society of America, West Virginia Chapter, Records, 1946/19652
- Somerville family papers, 1821/201323
- Stewart Plein, Librarian and Collector, Papers, 1880/2025, bulk 1896/19341
- Storer College Administrative and Operational Records, 1865/1960, bulk 1930/1950204
- Strother Family Papers, 1846/19905
- Stuart Family Papers, 1785/18801
- Summers County (W. Va.) Court Records and Miscellaneous Papers, 1859/194985