- Sally Jane Brown, Artist, Collection, 1959/2023, bulk 2013/20208
- Sam Huff, West Virginia University and National Football League Football Player, Papers, 1930/2019, bulk 1955/20101
- Samuel Vaughan Wilson Papers, 1945/20174
- Sanjay Suchak photographs, 2017/20211
- School of Business records, 1929/20223
- Senator John D. (Jay) Rockefeller IV papers, 1960/2015, bulk 1985/20142
- Seven Society records, 2006/20081
- Sexual Orientation, Gender Identity and Expression (SOGIE) Programming Records, 1984/20243
- Sharp family history papers, 1980/20192
- Shawn Walker Ephemera Collection, 1964/20181
- Shelley L. Dowling papers, 1904/20197
- Shenandoah County Library System Collection, 1911/20212
- Shenandoah Valley Bicycle Coalition Records, 1977/20197
- Shenandoah Valley Equality Collection, 2002/20221
- Side by Side records, 1975/2023, bulk 1990/202321