- Larry McBryde Collection on the John McLaren McBryde Family, 1859/20133
- Linda Kiisk Architectural Collection, 1968/20131
- Lucy Herndon Crockett Papers, 1940/20153
- M. Rupert Cutler Papers, 1930/2021, bulk 1962/2021194
- Mary Anne Shephard Manuscript, 1847/20161
- Mel Felton and the Southern Colonels Recordings, 1946/20141
- Melinda E. Pittman Theatrical Collection, 1974/2012, bulk 1990/20081
- Menu Collection, 1939/20181
- Merle Easton Architectural Collection, 1966/20132
- Milka Bliznakov Prize Records, 1999/20191
- Natalie de Blois Architectural Collection, 1941/20132
- New River Community Action, Inc., Records, 1966/20152
- Peacock-Harper Culinary History Friends Records, 1999/20192
- Records of HokiePRIDE, 1971/2015, bulk 1995/201315
- Records of Virginia Tech National Capital Region, 1991/20146