- Sally H. Thomas papers, 1968/20101
- Sally Jane Brown, Artist, Collection, 1959/2023, bulk 2013/20206
- Sam Huff, West Virginia University and National Football League Football Player, Papers, 1930/2019, bulk 1955/20101
- Sam McColloch, Compiler, Three Manuscripts regarding Family History, Artists, and Fighter Pilot, 1904/20141
- Samuel F. Harsh Family, Genealogy, Photographs, and Artifacts, 1860/2011, bulk 1860/19101
- Samuel Spencer Stone, Compiler, Stone Family Papers, 1870/19981
- Samuel Vaughan Wilson Papers, 1945/201765
- Sarah Pillsbury Harkness Architectural Collection, 1986/20132
- Schola Cantorum Records, 1995/201618
- School of Architecture student records from Professor Michael Bednar courses, 1972/20112
- School of Business records, 1929/20227
- School of Theatre and Dance Records, 1930/2011, bulk 1981/19932
- Scott Donaldson Papers, 1970/20122
- Scottish Coalition USA Archives, 1980/20114
- Scrapbooks, 1914/20112