- C-SPAN records, 1809/2012, bulk 1978/201236
- C. Barrett Graham papers, 1967/20161
- C. Edwin Baker Papers, 1886/2013, bulk 1970/20091
- C. Ernest Edgar III papers, 1956/20101
- Cabell Family Homes and Graveyards Collection, 2008/20121
- Cadet Life, Organizations, and Activities, 18451
- Calendars Collection, 1910/20131
- Canterbury Association Records, 1954/2013, bulk 1980/20004
- Capital Club of Williamsburg Records, 1960/2015, bulk 1970/20005
- Carl A. "Pappy" Fehr papers, 1907/2012, bulk 1945/19742
- Carlin Family Genealogy, 1886/20151
- Carol B. Hannum Drawings of Dogs, 1997/20184
- Carol Barton papers, 1973/202018
- Carol Berger Chicago performing arts playbills collection, 1988/20154
- Carol J. Bell, Memorabilia of West Virginia University Medical Technology Program, 1968/2012, bulk 19681