- 1x1 Japan Exhibition Materials, 1965-2024, 20244
- A. J. Davis Family Collection, 1874/2007, bulk 1874/19071
- Abbye A. Gorin Architectural Collection, 1940/2006, bulk 1995/20061
- Alfred C. Payne Collection, 1917/20031
- Alleghany Chapter, National Society of the Daughters of the American Revolution Records,, 1890/202211
- American Egg Board Collection, 1974/20044
- Ann A. Hertzler Collection, 1863/2013, bulk 1974/20002
- Anna Alexandrovna Shchetinina Architectural Collection, 2001/20052
- Anna P. Sokolina Architectural Collection, 1924/201911
- Anne Price Yates Papers II, 1898/20053
- Appalachian History Films, 1981/20051
- Appalachian Regional Commission Teaching Project Records,, 2001/20062
- Benjamin Huddle Diary, 1861/20062
- Betty L. Moss Architectural Collection, 1950/20074
- Blacksburg Baptist Church Records, 1894/20072