- Betty L. Moss Architectural Collection, 1950/20074
- Blacksburg Baptist Church Records, 1894/20071
- Blacksburg Electronic Village Collection, 1992/20061
- Blanche Lemco van Ginkel Architectural Collection, 1956/20134
- Campus Guide, Virginia Tech, 20021
- Carmen Espegel Alonso Architectural Collection, 1985/20041
- Carol O'Neale Culnan Architectural Collection, 1966/20161
- Carter/Cash Family Collection, 1940/200912
- Center of Contemporary Architecture Media Collection, 2000/2009, bulk 2000/20031
- Charles Walls Collection, 1882/20032
- Civil War Small Manuscripts Collection, 1861/19961
- Craig L. Brians Papers, 1992/201344
- Czeslawa Zielinska Architectural Collection, 1964/2005, bulk 1966/19795
- Dean Carter Papers, 1950/2003, bulk 1964/19823
- Department of Biochemistry Oral History Collection, 2001/200512