- "Hokie" Wooden Sculpture, 20011
- Anna Alexandrovna Shchetinina Architectural Collection, 2001/20051
- Anna P. Sokolina Architectural Collection, 1924/20191
- Betty L. Moss Architectural Collection, 1950/20074
- Department of Biochemistry Oral History Collection, 2001/20056
- Despina Stratigakos Architectural Collection, 1998/20132
- James I. Robertson Jr. Papers, 1849/20112
- Joyce Oron Architectural Collection, 1954/20052
- Lynne Olver Collection, 20151
- M. Rupert Cutler Papers, 1930/2021, bulk 1962/20217
- Melinda E. Pittman Theatrical Collection, 1974/2012, bulk 1990/20083
- Multicultural Diversity Oral History Collection, 1987/2002, bulk 2001/20029
- Natalie de Blois Architectural Collection, 1941/20131
- New River Community Action, Inc., Records, 1966/20151
- Newport and Clover Hollow, Giles County History Collection,, 1904/20062