- Bradley and Brian Flota comic book collection, 1952/2008, bulk 1960/19993
- Carol Barton papers, 1973/202019
- Charles Grattan Price Jr. collection on Tweetsie and the Shenandoah Central Railroad, 1916/1997, bulk 1948/19565
- Charles T. Smith photographs, 1880/2007, bulk 1990/199929
- Christine Hoepfner Collection on the Shenandoah National Park, 1911/20007
- Civil War Miscellaneous Collection, 1860/2005, bulk 1862/19281
- College of Integrated Science and Technology (CISAT) records, 1987/200442
- Common Ground Records, 1983/20038
- Delta Sigma Theta Sorority, Inc. Iota Alpha Chapter 50th anniversary collection, 1973/20182
- Dennis Pluchinsky collection on terrorism and counterterrorism, 1956/201678
- Department of Living Sciences records, 1915/20034
- Dorothy Lee Baugher papers, 1936/2003, bulk 1975/19815
- Dudley and Rexrode Family Papers, 1873/20055
- Eldon Bowman collection of Bowman family papers, 1797/201917
- Elizabeth "Libby" Custer Papers, 1930/19973