- Admiral Thomas J. Lopez Papers, 1973/20141
- Alan Clarke Railroad Research Papers, 1861/20124
- Armstead L. Robinson papers, 1848/2001, bulk 1967/19924
- Arthur Jacknowitz Faculty Papers, 1954/20193
- Ben Freedman, Artist and Professor, Papers and Artwork, 1960/20004
- Bradley H. Patterson, Jr. papers, 1943/201732
- Charles Peters, Editor and Author, Papers, 1975/201617
- Charleston Gazette Publishing Company Records and Chilton Family Papers, 1884/20183
- Don Knotts, Actor, Scripts, Sound Recordings, and Other Material, 1946/2006, bulk 1966/20002
- Dr. William A. Neal Papers, 1880/20164
- Emory L. Kemp Papers regarding Industrial History, 1735/20217
- Ewell Snuffer, Mine Foreman and Inspector, Diaries, 1955/19971
- Forbes, Anderson, and Hildebrand Families, Correspondence and Other Material, 1862/20131
- Francis H. Fife papers, 1785/2015, bulk 1940/20152
- Frank Gardiner Wisner papers, 1909/19971