- Saint Andrew's Society collection, 1861/199512
- Sallie Bennett Papers regarding World War I Flying Ace Louis Bennett, Jr., 1873/2009, bulk 1904/19262
- Sally H. Thomas papers, 1968/201058
- Sally Jane Brown, Artist, Collection, 1959/2023, bulk 2013/20203
- Sally Waldner Bould Stan Architectural Collection, 1940/19972
- Sam Huff, West Virginia University and National Football League Football Player, Papers, 1930/2019, bulk 1955/20101
- Sam McColloch, Compiler, Three Manuscripts regarding Family History, Artists, and Fighter Pilot, 1904/20141
- Sam McColloch, Photographer, Photographic Prints, 1983/19995
- Sam Sadler papers, 1960/200825
- Sam di Bonaventura papers, 1900/199816
- Samuel F. Harsh Family, Genealogy, Photographs, and Artifacts, 1860/2011, bulk 1860/19101
- Samuel Spencer Stone, Compiler, Stone Family Papers, 1870/19984
- Samuel Vaughan Wilson Papers, 1945/2017162
- Sanborn Insurance Atlas, Williamsburg, Virginia Collection, 1930/2007, bulk 1930/19601
- Sarah Bonwell Hudgins Foundation Records, 1963/19993