- Albert L. Sturm Papers, 1904/19881
- Alfred C. Payne Collection, 1917/20031
- American Work Horse Museum Collection, 1971/19991
- Ann A. Hertzler Collection, 1863/2013, bulk 1974/20001
- Appalachian Oral History Project, 1986/19911
- Black Women at Virginia Tech Oral History Project Records, 1967/2000, bulk 1994/20001
- C. David Loeks Papers, 1947/19971
- Carrie T. Sibold Family Papers, 1912/1990, bulk 1974/19901
- Charles Burchard Collection, 1935/19891
- Charles Goodsell Collection, 1982/20011
- Charles Sears Oral History Interview, 19881
- Christopher C. Kraft Papers, 1941/1998, bulk 1941/19821
- Clarence Trent Papers, 1958/19911
- College of Agriculture and Life Sciences (CALS) Collection, 1900/20011
- College of Education History Records, 1970/19901