- Albert L. Sturm Papers, 1904/19881
- Alfred C. Payne Collection, 1917/20031
- American Work Horse Museum Collection, 1971/19991
- Ann A. Hertzler Collection, 1863/2013, bulk 1974/20001
- Arthur M. Squires Papers, 1888/1987, bulk 1940/19871
- Black Women at Virginia Tech Oral History Project Records, 1967/2000, bulk 1994/20001
- Blacksburg Chamber Music Series Collection, 1967/19821
- C. David Loeks Papers, 1947/19971
- C. Eugene Rowe Papers, 1949/19871
- Campus Guide to Virginia Tech, 19781
- Carl T. Herakovich Papers, 1973/19871
- Carol M. Newman, Jr., Papers, 1930/19871
- Carrie T. Sibold Family Papers, 1912/1990, bulk 1974/19901
- Charles A. Kennedy Papers, 1963/19871
- Charles Burchard Collection, 1935/19891