- Charles Grattan Price Jr. collection on Tweetsie and the Shenandoah Central Railroad, 1916/1997, bulk 1948/19566
- Charles T. Smith photographs, 1880/2007, bulk 1990/19996
- Chesapeake Western Railway Company Records, 1916/198246
- Christine Hoepfner Collection on the Shenandoah National Park, 1911/20006
- Civil War Miscellaneous Collection, 1860/2005, bulk 1862/19283
- Daisy Bacon Papers, 1857/198612
- Davis & Associates architectural drawings, 1925/198651
- Davis, Kline, and Hutton Family papers, 1816/19776
- Delphine Hurst Parsons papers, 1923/1976, bulk 1923/19313
- Delta Sigma Theta Sorority, Inc. Iota Alpha Chapter 50th anniversary collection, 1973/20182
- Dennis Pluchinsky collection on terrorism and counterterrorism, 1956/201628
- Department of History: Raymond C. Dingledine, Jr. papers, 1950/19837
- Department of Living Sciences records, 1915/200332
- Dorothy Lee Baugher papers, 1936/2003, bulk 1975/19815
- Dorothy McKinley Spooner Garber Papers, 1925/19782