- Charles Burchard Collection, 1935/19891
- Charles S. Worley, Jr., Collection, 1950/19821
- Christopher C. Kraft Papers, 1941/1998, bulk 1941/19821
- Clarence Trent Papers, 1958/19911
- Clinton H. Cowgill Collection, 1916/19771
- College of Agriculture and Life Sciences (CALS) Collection,, 1900/20011
- Dan H. Pletta Papers, 1942/19961
- Dayton M. Kohler Papers, 1889/19711
- Dorothy McCombs Collection,, 1970/19891
- Dr. Richard Zallen Papers, 1940/20071
- Earl T. Swink Papers, 1949/19721
- Earle D. Gregory Collection, 1915/19971
- Edgemont Farm Papers, 1925/19981
- Elizabeth D. Guthrie Papers on the VPI Glee Club, 1940/19881
- Erwin Hoge Will Papers, 1918/19731