- Albert L. Sturm Papers, 1904/19881
- Alfred C. Payne Collection, 1917/20031
- Ann A. Hertzler Collection, 1863/2013, bulk 1974/20001
- Anne Price Yates Papers II, 1898/20051
- Antoine Gaujot and Julien E. Gaujot Papers, 1840/19991
- Arthur M. Squires Papers, 1888/1987, bulk 1940/19871
- Benjamin Cottrell Papers, 1910/19831
- Beulah O. Allen Collection,, 1905/1992, bulk 1920/19701
- Black Women at Virginia Tech Oral History Project Records, 1967/2000, bulk 1994/20001
- Blacksburg Chamber Music Series Collection, 1967/19821
- Byron Nelson Cooper Papers, 1925/19711
- C. Eugene Rowe Papers, 1949/19871
- Carol M. Newman, Jr., Papers, 1930/19871
- Carrie T. Sibold Family Papers, 1912/1990, bulk 1974/19901
- Charles A. Kennedy Papers,, 1963/19871