- Albert L. Sturm Papers, 1904/19883
- Alfred C. Payne Collection, 1917/20031
- Alice Langley Hsieh Papers, 1943/19784
- Alleghany Chapter, National Society of the Daughters of the American Revolution Records, 1890/20222
- Ann A. Hertzler Collection, 1863/2013, bulk 1974/20002
- Association for Women in Architecture Records, 1928/19923
- Bailey-Law Collection, 1825/19714
- Beverly Willis Architectural Collection, 1954/19995
- Black, Kent, and Apperson Family Papers, 1779/19844
- Blacksburg Baptist Church Records, 1894/20078
- Carter/Cash Family Collection, 1940/20092
- Charles Burchard Collection, 1935/198921
- Dorothee Stelzer King Architectural Collection, 1950/20182
- Earl A. Thornton Papers, 1885/20002
- Earle D. Gregory Collection, 1915/19975