- Charles Lietwiler transportation collection, 1903/20052
- Charles M. Robinson and Principals Architectural Records, 1855/20121
- Charles Rodrigues playbill collection, 1879/20098
- Charleston Gazette Publishing Company Records and Chilton Family Papers, 1884/201812
- Clan MacLeod Society USA Records, 1899/202243
- Clarence L. Townes, Jr. papers, 1944/19883
- Claude Moore Health Sciences Library records, 1848/2019, bulk 1942/20251
- Clubs and Organizations, 19301
- Coleman-Kimbrough papers, 1870/19923
- Coleman-Wilson Papers, 1775/1989, bulk 1883/19645
- Collateral and Other Publications (PB-05), 1952/20232
- Conklin and Rossant Reston project collection, 1960/19904
- Cook Family Papers, 1872/19779
- Curtis West Harris and Ruth Jones Harris Papers, 1950/20124
- Dabney Lancaster and Lancaster Family Records, 1848/19741