- A. Edwin Kendrew Papers, 1930/19591
- A. H. Hand Papers, 1835/20091
- A. Willis Robertson Papers, 1921/1988, bulk 1946/19661
- Adam Empie Papers, 1811/2004, bulk 1811/18501
- Adele Blow Chatfield-Taylor family papers, 1899/19771
- African American Family Photographs, 1880/19601
- Albert E. Garrett, Jr. scrapbook, 1927/19741
- Albert E. Haak Scrapbook, 1947/19771
- Alexander Kallos Papers, 1939/19591
- Alfred R. Armstrong Papers, 1928/19761
- Allen-Kean-Laurence family letters, 1837/19601
- Althea Hunt Papers, 1926/19611
- Alumni Association Records, 1833/2014, bulk 1950/20051
- Alvin Duke Chandler Papers, 1896/1984, bulk 1950/19601
- American Association of University Professors, College of William and Mary Chapter Records, 1924/1979, bulk 1924/19791