- Adolphus DeBussey, Soldier, Civil War Letters, 1861/1998, bulk 1861/18711
- Alan Clarke Railroad Research Papers, 1861/20122
- Ancella Bickley, Historian, Research Papers regarding African-Americans, 1775/2018, bulk 1970/20119
- Anna Schein, Collector, Feedsack Textile Bag Collection, 1925/19656
- Appalachian Prints Collection, 1839/2010, bulk 1859/19092
- Asa Orin Bishop Papers, 1910/19905
- Barbara Howe, History Professor, Research Papers regarding the History of the College of Arts and Sciences, 1870/2005, bulk 1990/20053
- Barnette Collection, Lawyer, Businessman, Educator, Philanthropist, and Chairman Emeritus of Bethlehem Steel Corporation, 1905/20201
- Braxton County (W. Va.) Court Records and Miscellaneous Papers, 1830/19532
- Breece Pancake, Author, Papers, 1925/2000, bulk 1966/19941
- Capt. William Sommerville (1756-1826) Papers, 1799/18881
- Carroll Wilkinson Papers, 1914/2018, bulk 1979/20181
- Chapman Revercomb, Politician, Biography, 1932/19991
- Charles Peters, Editor and Author, Papers, 1975/20161
- Charleston Gazette Publishing Company Records and Chilton Family Papers, 1884/20188