- Armistead Boothe Papers (MS164), 1803/19904
- Arthur E. Scott photograph collection13
- Arthur E. Scott photograph collection, 1910/197613
- Association for Women in Architecture Records, 1928/19921
- Audio Visual Collection, 1928/20154
- Bailey-Law Collection, 1825/19716
- Benjamin A. Banks Papers, 1855/197412
- Benjamin L. Wigfall Artist Archives and Mary Carter Wigfall Personal Papers, 1880/20237
- Bertha Fanning Taylor Papers, 1905/19774
- Betty Brown Clemmer and Willis Clemmer papers, 1920/2015, bulk 1943/19492
- Black, Kent, and Apperson Family Papers, 1779/19847
- Blacksburg Baptist Church Records, 1894/20079
- Blair family papers, 1821/19492
- Blow Family Papers, 1613/1960, bulk 1770/18752
- Board of Visitors Records, 1920/20102