- Blair family papers, 1821/19491
- Carter Glass Papers, 1820/19468
- Charles M. Robinson and Principals Architectural Records, 1855/20121
- Claude Moore Health Sciences Library records, 1848/2019, bulk 1942/20251
- Dorothy Sandridge Gloor Papers (Eighth Evacuation Unit Hospital), 1935/20146
- Duke family law firm papers, 1820/19591
- Herbert Friedman Holocaust materials, 1924/20061
- John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/18652
- John W. Warner papers, 1967/2009, bulk 1967/20082
- Lewis M. Dabney III papers on Edmund Wilson; William Faulkner and the Yoknapatawpha; and Crystal Ross and John Dos Passos., 1895/20053
- Milton L. Grigg Papers, 1929/19983
- Monroe Leigh papers, 1941/20011
- Ravindra S. Khare papers, 1938/20171
- University of Virginia Medical Center records, 1857/20243
- University of Virginia School of Medicine records, 1825/20206