- Albert L. Sturm Papers, 1904/19881
- Alfred C. Payne Collection, 1917/20031
- Alice Langley Hsieh Papers, 1943/19781
- Alleghany Chapter, National Society of the Daughters of the American Revolution Records, 1890/20221
- Association for Women in Architecture Records, 1928/19921
- Bailey-Law Collection, 1825/19716
- Black, Kent, and Apperson Family Papers, 1779/19847
- Blacksburg Baptist Church Records, 1894/20076
- Carter/Cash Family Collection, 1940/20091
- Charles Burchard Collection, 1935/198913
- Charles Willis Cassell Family Papers, 1883/19501
- Dillard-Larkin Family Papers, 1809/19551
- Dorothee Stelzer King Architectural Collection, 1950/20181
- Earl A. Thornton Papers, 1885/20001
- Earle D. Gregory Collection, 1915/19974