- Al Gross Papers, 1909/20006
- Alice Langley Hsieh Papers, 1943/19781
- Annie M. Hale Sheet Music Collection, 1892/19872
- Aviation Brochures and Pamphlets Collection, 1910/19581
- Bailey-Law Collection, 1825/1971143
- Benjamin Cottrell Papers, 1910/19831
- Betty L. Moss Architectural Collection, 1950/20071
- Buckhorn Coal Company Records, 1880/19613
- Carroll and Wythe Counties Industries Collection, 1937/19801
- Chapman J. French Papers, 1903/195749
- Christiansburg [Virginia] Industrial Institute Historical Documents, 1866/19912
- Conan W. Vaughan, Jr., Papers, 1923/199213
- Cynthia Addington Boatwright Papers, 1930/19901
- Dayton M. Kohler Papers, 1889/19715
- Earle D. Gregory Collection, 1915/19978