- Anderson Family papers, 1755/19581
- Campbell Family Papers, 1843/19501
- Collection of Photographs of Lexington, Va., 1857/19691
- David C. Irwin Collection, 1869/1937, bulk 1887/19371
- Graham Philanthropic Society records, 1809/19421
- Irwin Taylor Sanders Papers, 1925/19501
- Lexington Life Saving and First Aid Crew Collection, 1935/19851
- Lexington, Virginia, 1818/19912
- Maps, 1890/19501
- Photograph and Postcard of Ann Smith Academy, 1900/19801
- Photograph of a Lexington, Va. man with a cleft lip and palate, 1910/19401
- Quisenberry Family Papers, 1900/19501
- Robert E. Lee Family papers, 1792/1935, bulk 1833/18701
- Rockbridge Historical Society files on Houses, 1800/19951
- Rockbridge Historical Society files on government, 1803/19521