- Effinger School Collection, 1909/20115
- Elisha Franklin Paxton papers, 1808/1981, bulk 1853/18632
- Ellinor Porcher Gadsden Papers, 1839/19755
- Elsie Ball Wright Bowley Papers, 1929/197212
- Emily Houston Brown Walker Scrapbook, 1934/19361
- Essay, "Colored People in Buffalo District, 1890 - 1957", 1890/19571
- Fitzgerald Flournoy papers, 1912/19631
- Fortnightly Club Papers, 1900/20159
- Four Images (originals and copies) of McCown Springs, near Williamsville, Bath County, Va., 1920/19501
- Francis P. Gaines Papers, 1803/19791
- Frank J. Gilliam Papers, 1914/19641
- Frank Parsons papers, 1891/19991
- Frank Smith Reader diary and transcription, 1863/19641
- Franklin Society and Library Company collection, 1838/19712
- Frederick William McWane collection, 1909/19593