- Coray S. Brown family photograph collection, 1910/19603
- Cralle and Hurt Family Papers, 1801/20053
- Dale L. Walker Research Collection, 1914/19851
- David C. Irwin Collection, 1869/1937, bulk 1887/19371
- Davidson Family Papers, 1870/197512
- Davis Family Diaries, 1917/1959, bulk 1917/19332
- Democratic Party Ephemera Collection, 1912/1961, bulk 1912/19281
- Dickinson Family Financial Records Collection, 1900/19485
- Diehl and Zink Family Papers, 1905/19801
- Dillon Family Papers, 1805/19443
- Donna Huffer research notes for book, "Fare Thee Well, Ole Joe Clark", 20172
- Douglas Southall Freeman Correspondence, 1934/19361
- East Lexington (Va.) Covered Bridge collection, 1934/19773
- Edmund Charles Blunden Correspondence, 1934/19351
- Edward Felix Turner, Jr. collection, 1902/193925