- 4-H Club (Chesterfield County, Va.) minute books, 1933/19411
- A. H. Hand Papers, 1835/20091
- A. K. Leake Papers, 1872/19401
- A. Willis Robertson Papers, 1921/1988, bulk 1946/196629
- Abbot E. Smith Papers, 1930/19392
- Adam Empie Papers, 1811/2004, bulk 1811/18502
- Adele Blow Chatfield-Taylor family papers, 1899/197723
- African American Family Photographs, 1880/19603
- Alfred R. Armstrong Papers, 1928/19761
- Althea Hunt Papers, 1926/196114
- Alumni Association Records, 1833/2014, bulk 1950/200515
- Alvin Duke Chandler Papers, 1896/1984, bulk 1950/19601
- American Association of University Professors, College of William and Mary Chapter Records, 1924/1979, bulk 1924/19795
- Amos Koontz Papers II, 1865/197016
- Anatole and Vladimir Kalichevsky Papers, 1871/19551