- duPont family papers, 1767/1982207
- Records of the Office of the President, Julian A. Burruss, 1906/1946197
- Carter Glass Papers, 1820/1946190
- Duke family law firm papers, 1820/1959185
- Roy Bird Cook (1886-1961), Collector, Papers, 1679/1984, bulk 1840/1960181
- Historical Photograph Collection, 1850/2010177
- Office of the President. Julian Alvin Carroll Chandler Records, 1919/1934174
- Bailey-Law Collection, 1825/1971173
- Restoration Files for the Historic Structures Report, 1750/2005160
- Adele Goodman Clark papers, 1849/1978155
- West Virginia University, President's Office, Departmental, and Other Records, 1864/1989, bulk 1867/1920138
- Records of the Virginia Agricultural Experiment Station, 1903/1947131
- Fries Textile Plant Records, 1900/1988127
- Records of the Virginia Cooperative Extension, 1862/1997121
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/1900118