- A. H. Hand Papers, 1835/20091
- A. K. Leake Papers, 1872/19401
- A. Willis Robertson Papers, 1921/1988, bulk 1946/196616
- Abbot E. Smith Papers, 1930/19392
- Adam Empie Papers, 1811/2004, bulk 1811/18502
- Adele Blow Chatfield-Taylor family papers, 1899/197722
- African American Family Photographs, 1880/19603
- Althea Hunt Papers, 1926/196123
- Alumni Association Records, 1833/2014, bulk 1950/200514
- Alvin Duke Chandler Papers, 1896/1984, bulk 1950/19601
- American Association of University Professors, College of William and Mary Chapter Records, 1924/1979, bulk 1924/19796
- Amos Koontz Papers II, 1865/197016
- Anatole and Vladimir Kalichevsky Papers, 1871/19551
- Ann Coffey Papers, 1924/19401
- Anne T. Chapman Papers, 1884/19541