- S. Corder Musgrave Papers, 1891/19661
- S. F. (Bill) Royall, Jr. papers, 1883/19791
- S. George Company Records, 1900/19751
- S. Maria Elliott Family Collection, 1826/19421
- S. Vernon McCasland papers, 1928/19541
- S.A. Thompson Family Papers, 1899/19305
- S.A. Thompson Legal Papers, 1919/19321
- Saint Andrew's Society collection, 1861/199510
- Salem Movie Theater, 19301
- Sallie Bennett Papers regarding World War I Flying Ace Louis Bennett, Jr., 1873/2009, bulk 1904/19266
- Sallie Key Meyers account of Zuni culture, 19302
- Salt Sulphur Springs Records, 1819/19321
- Salvation Army Combined Corps Roll and Ledger, 1926/1980, bulk 1928/19692
- Sam Bowman Papers, 1848/19672
- Sam Huff, West Virginia University and National Football League Football Player, Papers, 1930/2019, bulk 1955/20101