- Calder Smith Sherwood, III Papers, 1899/19763
- Calvert Walke Tazewell Papers, 1900/19972
- Carl Van Vechten - Mark Lutz Collection, 1881/19805
- Carolyn Rhodes Papers, 1924/20191
- Carter Glass Papers, 1820/194612
- Cazenove Family Papers (MS212), 1786/19707
- Charles Burchard Collection, 1935/19891
- Charles E. Hewins Papers, 1856/19511
- Charles M. Robinson and Principals Architectural Records, 1855/20121
- Charles Rodrigues playbill collection, 1879/20095
- Charles Willis Cassell Family Papers, 1883/19509
- Charleston Gazette Publishing Company Records and Chilton Family Papers, 1884/20185
- Clan MacLeod Society USA Records, 1899/20222
- Coleman-Kimbrough papers, 1870/19923
- Coleman-Wilson Papers, 1775/1989, bulk 1883/19645