- Siler Family Papers, 1848/19681,153
- Long/Trail Southeastern West Virginia Historical Records, 1870/2025586
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974496
- Gregory A. Prince Mormon Studies Collection, 1813/2020419
- Farrier Family Papers, 1894/1972354
- Edward L. Stone/Borderland Coal Company Papers
1895-1937346
- The University of Virginia Anatomy Laboratory Lantern Slides collection, 1920/1965325
- W. Jett Lauck papers, 1900/1952304
- G. Walter Mapp Papers, 1873/1941286
- Duke family law firm papers, 1820/1959255
- Episcopal Diocese of Southwestern Virginia Records, 1866/2004, bulk 1919/1969248
- Samuel Davis Stokes Papers, 1915/1925228
- Records of the Office of the President, Julian A. Burruss, 1906/1946217
- West Virginia University, President's Office, Records, 1864/1989216
- Bailey-Law Collection, 1825/1971214