- A.S. Hammack papers, 1864/19541
- Albert Moore Reese, Zoology Professor, Miscellaneous Items, 1900/19701
- Charles Willis Cassell Family Papers, 1883/19503
- Edward G. Carson Papers, 1924/2004, bulk 1970/20001
- Episcopal Diocese of Southwestern Virginia Records, 1866/2004, bulk 1919/196912
- Records of the Board of Visitors, 1908/20102
- Records of the Virginia Cooperative Extension, 1862/19976
- Records of the Virginia Tech Board of Visitors, 1873/20096
- Roy Jay Holden Papers, 1904/19451
- Ruth and Lowell Toliver Collection of Newman Family Papers, 1875/20051
- U.S. Forest Service, George Washington National Forest, Dry River District records, 1917/19941
- University History, 19081