- Carlton Casey Papers, 1894/19991
- Cocke and Related Family Papers, ca.1773-19921
- Cumming Family Papers, 1818/19921
- Earl A. Thornton Papers, 1885/20001
- John Alexander Graham Papers, 1910/1947, bulk 1915/19471
- John Edward Williams Papers, 1892/19401
- Mills E. Godwin, Jr. Papers, 1712/1989, bulk 1947/19891
- Polly Ney Zindler correspondence, 1922/19581
- Records of the Board of Visitors, 1908/20101
- Robert E. Lee Family papers, 1792/1935, bulk 1833/18701
- Robert Morton Hughes Papers, 1715/1940, bulk 1871/19331
- Thomas Jefferson papers, 1761/19311