- Siler Family Papers, 1848/19681,160
- Long/Trail Southeastern West Virginia Historical Records, 1870/2025575
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974475
- W. Jett Lauck papers, 1900/1952475
- Gregory A. Prince Mormon Studies Collection, 1813/2020412
- The University of Virginia Anatomy Laboratory Lantern Slides collection, 1920/1965325
- Edward L. Stone/Borderland Coal Company Papers
1895-1937313
- Carter Glass Papers, 1820/1946300
- Papers of the Low Moor Iron Company
1873-1927275
- duPont family papers, 1767/1982267
- Samuel Davis Stokes Papers, 1915/1925228
- Farrier Family Papers, 1894/1972221
- Bailey-Law Collection, 1825/1971201
- Fries Textile Plant Records, 1900/1988201
- Records of the Office of the President, Julian A. Burruss, 1906/1946198